PKM2 anticorps (AA 399-403)

N° du produit ABIN783340

Cet anticorps Lapin Polyclonal détecte spécifiquement PKM2 dans WB. Il présente une réactivité envers Humain et Souris.

Aperçu rapide pour PKM2 anticorps (AA 399-403) (ABIN783340)

Antigène: PKM2 (Pyruvate Kinase M2 (PKM2))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PKM2 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-PKM2 anticorps

Épitope: AA 399-403

Séquence: V-R-A-S-S

Specificité: This antibody detects endogenous levels of total PKM1 protein.

Réactivité croisée (Details): Species reactivity (tested):Human, Mouse

Purification: Affinity-chromatography using epitope-specific peptide

Immunogène: Peptide sequence around aa. 399~403

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store (in aliquots) at -20 °C.

Détails sur PKM2

Antigène: PKM2 (Pyruvate Kinase M2 (PKM2))

Autre désignation: PKM2

Sujet: Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.Synonyms: CTHBP, Cytosolic thyroid hormone-binding protein, M2-PK, OIP-3, OIP3, Opa-interacting protein 3, PK2, PK3, PKM, Pyruvate kinase 2/3, Pyruvate kinase M1/M2, Pyruvate kinase isozymes M1/M2, Pyruvate kinase muscle, Pyruvate kinase muscle isozyme, THBP1

Poids moléculaire: 60 kDa

ID gène: 5315

NCBI Accession: NP_002645

UniProt: P14618

Pathways: L'effet Warburg